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Molecular and Cellular Biosciences at Wake Forest University


Wake Forest University Graduate School » Molecular and Cellular Biosciences

Bridget Brosnihan Simmons, Ph.D.

Bridget Brosnihan Simmons, Ph.D.
Education & Training BS College of St Mary 1965 MS Creighton University 1970 PhD Case Western Reserve 1974 Fellowship Cleveland Clinic Foundation 1976 Memberships American Heart Association American Physiological Society Consortium of Se Hypertension Centers Endocrine Society

 

Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.

 

Valdes G, Corthorn J, Bharadwaj MS, Joyner J, Schneider D, Brosnihan KB.Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig. Reprod Biol Endocrinol. 2013;11():5.

 

Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB.AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013;34(6):497-502.

 

Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013;26(5):583-590.

 

Americao A, Pirro N, Brosnihan KB, Chappell M. Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. FASEB J. 2013;27():909.1.

 

Brosnihan KB, Bharadwaj MS, Yamaleyeva LM, Neves LAA. Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Placenta. 2012;33(1):17-23.

 

Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012;302(11):F1374-84.

 

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

 

Yamaleyeva LM, Lindsey SH, Pulgar VM, Yamane L, daSilva M, Bonfa P, Brosnihan KB. ACE2 deficiency enhances angiotensin II-induced vasoconstriction of the uterine artery at mid-gestation in mice [abstract]. Hypertension. 2012;60(Suppl 3):317.

 

Alzayadneh EM, Brosnihan KB, Diz DI. Nuclear renin-angiotensin system in renal proximal tubule cells [abstract]. Hypertension. 2012;60(3 Suppl):238.

 

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Hypertension. 2012;60(Suppl 3):283.

 

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM. Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b358.

 

Bharadwaj MS, Brosnihan KB. Role of endogenous angiotensin-(1-7) in the regulation of prostaglandin synthetic enzymes in the uteroplacental unit in late gestation [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b540.

 

Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.

 

Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.

 

Hering L, Herse F, Brosnihan KB, Muller DN, Dechend R. Effects of circulating and local angiotensin II on maternal and fetal hearts during pregnancy [abstract]. Placenta. 2011;32(9):A40.

 

Bharadwaj MS, Joyner J, Corthorn J, Valdes G, Brosnihan KB. Angiotensin-(1-7) and ACE2 uteroplacental expression in guinea-pig pregnancy [abstract]. Hypertension. 2011;58(5):e171.

 

Firmes L, Brosnihan B, dos Reis A. Effect of ovariectomy on renin angiotensin system in aged rats [abstract]. Hypertension. 2011;58(5):e147.

 

Gwathmey TM, Nixon PA, O'Shea TM, Brosnihan KB, Chappell MC, Washburn LK.Premature birth is associated with higher diastolic blood pressure and reduced vitamin D in African American adolescents [abstract]. Hypertension. 2011;58(5):e165.

 

Muller C, Shewale S, Pirro N, Gurley SB, Brosnihan KB, Fiorino P, Chappell MC.Sex and species differences in ACE, ACE2 and neprilysin of the renal brush border [abstract]. Hypertension. 2011;58(5):e153.

 

Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin EL, Ferrario CM. Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy. Russ J Cardiol. 2011;4():102-108.

 

Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.

 

Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, Schuster M, Brosnihan KB, Ferrario CM, et al. Targeting the degradation of angiotensin II with recombinant angiotensin-convertng enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010;55(1):90-98.

 

Brosnihan KB, Hering L, Dechend R, Chappell MC, Herse F. Increased angiotensin II in the mesometrial triangle of a transgenic rat model of preeclampsia. Hypertension. 2010;55(2 Pt 2):562-566.

 

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

 

Senador D, Key M, Brosnihan KB, Irigoyen MC, Elased KM, Morris M.Cardiovascular interactions between losartan and fructose in mice. J Cardiovasc Pharmacol Ther. 2010;15(1):68-77.

 

Bharadwaj MS, Brosnihan KB. Decidualization results in the polarization of Ang-(1-7), Ang II, and ACE2 to the antimesometrial pole [abstract]. FASEB J. 2010;24(Meeting Abstracts):1040.8.

 

Bushnell C, Archer D, Brosnihan B. Vascular cell adhesion molecule-1 (VCAM-1) levels in patients at risk for stroke: the impact of gender and risk factor load [abstract]. Stroke. 2010;41(4):E302.

 

Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC.Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299(1):F35-F42.

 

Hering L, Herse F, Geusens N, Verlohren S, Wenzel K, Staff AC, Brosnihan KB, Huppertz B, Luft FC, Muller DN, et al. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension. 2010;56(2):311-318.

 

Anton L, Merrill DC, Neves LAA, Gruver C, Moorefield C, Brosnihan KB.Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an in vitro study. Reprod Biol Endocrinol. 2010;8():art. 135.

 

Bharadwaj MS, Brosnihan KB. Decidualization results: in the polarization of Ang-(1-7), Ang II, and ACE2 to the antimesometrial pole [abstract]. Hypertension. 2010;56(5):e114.

 

Brosnihan KB, Bharadwaj MS, Strawn WB, Busalacchi K, Horta CO, Gurley SB.Restricted maternal and fetal growth in angiotensin converting enzyme 2 knock out mice is associated with elevated placental angiotensin II levels [abstract]. Hypertension. 2010;56(5):e113.

 

Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. Protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling. Russ J Cardiol. 2010;5():83-90.

 

Varagic J, Ahmad S, Brosnihan KB, Habibi J, Sowers JR, Ferrario CM. The effects of nebivolol on salt-induced renal injury [abstract]. Hypertension. 2010;56(5):e155.

 

Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM.Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol. 2010;32(6):557-566.

 

 

Alfany-Frenandez I, Casillas-Ramirez A, Bintanel-Morcillo M, Brosnihan KB, Ferrario CM, Serafin A, Rimola A, Rodes J, Rosello-Catafau J, Peralta C.Therapeutic targets in liver transplantation: angiotensin II in nonsteatotic grafts and angiotensin-(1-7) in steatotic grafts. Am J Transplant. 2009;9(3):439-451.

 

Schindler C, Ferrario CM, Brosnihan KB, Idelevich E, Siegert J, Bocking W, Kirch W. Atorvastatin increases plasma levels of the pleiotropic RAS-peptide angiotensin-(1-7) in hypercholesterolemic patients [abstract]. Basic Clin Pharmacol Toxicol. 2009;104(6):517.

 

Alfany-Fernandez I, Casillas-Ramirez A, Bintanel-Morcillo M, Brosnihan KB, Ferrario CM, Rimola A, Arroyo V, Rodes J, Rosello-Catafau J, Peralta C.Therapeutic targets in liver transplantation: angiotensin II in non-steatotic grafts and angiotensin-(1-7) in steatotic grafts [abstract]. J Hepatol. 2009;50(Suppl 1):S63.

 

Schindler C, Ferrario CM, Brosnihan BK [sic] [Brosnihan KB], Idelevich E, Siegert J, Kirch W. Atorvastatin mediates pleiotropic effects in hypercholesterolemic patients via the Renin-Angiotensin-System (RAS) by increasing angiotensin-(1-7) [abstract]. Naunyn Schmiedebergs Arch Pharmacol. 2009;379(Suppl 1):92.

 

Sugulle M, Dechend R, Herse F, Weedon-Fekjaer MS, Johnsen GM, Brosnihan KB, Anton L, Luft FC, Wollert KC, Kempf T, et al. Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus. Hypertension. 2009;54(1):106-112.

 

Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009;150(8):3753-3758.

 

Anton L, Merrill DC, Neves LAA, Diz DI, Corthorn J, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB, et al. The uterine placental bed renin-angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009;150(9):4316-4325.

 

Valdes G, Kaufmann P, Corthorn J, Erices R, Brosnihan KB, Joyner-Grantham J.Vasodilator factors in the systemic and local adaptations to pregnancy. Reprod Biol Endocrinol. 2009;7():article 79.

 

Brosnihan KB, Dechend R, Hering L. Enhanced expression of human RAS mRNA in association with increased Ang II suggests a critical role for the maternal placenta in preeclampsia [abstract]. Hypertension. 2009;54(4):e111.

 

Dechend R, Hering L, Herse F, Verlohren S, Geusens N, Luft FC, Muller DN, Pijnenborg R, Brosnihan BK [sic] [Brosnihan KB], Cartwright JE. Different effects of circulating and local uteroplacental angiotensin II in pregnancy [abstract]. Hypertension. 2009;54(4):e108-e109.

 

Gilliam-Davis S, Tommasi EN, Garcia-Espinosa MA, Chappell MC, Brosnihan KB, Diz DI. Bilateral renal denervation prevents age-related proteinuria without altering excretion of intrarenal angiotensin peptides in Sprague-Dawley rats [abstract]. Hypertension. 2009;54(4):e76.

 

Varagic J, Ahmad S, Brosnihan KB, Ferrario CM. Spironolactone and angiotensin-(1-7) in salt-induced cardiac injury [abstract]. Hypertension. 2009;54(4):e26.

 

Brosnihan KB, Anton L, Merrill DC. Contrasting roles of the renin-angiotensin system in maternal uterus and fetal placenta in normal and preeclamptic pregnancy [abstract]. In: Meeting Program and Abstracts of the 2009 American Physiological Society Conference: Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathology; 2009 July 15-18; Broomfield (CO). 2009;():14.

 

Levy PJ, Strawn WB, Brosnihan KB, Moore LC, Holbrook JB, Hansen KJ, Ferrario CM. Angiotensin II receptor blockade increases endothelial repair potential in younger adults with severe peripheral arterial disease (PAD) [abstract]. J Thromb Haemost. 2009;7(Suppl 2):918.

 

Cardiac function , cross(mult/tnslat/inter)discip , education/training (all f, t, , hypertension , maternal & child health , metabolism , model development , molecular biology/molecular me , women's health issues.