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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

Charles E McCall, M.D.

Charles E McCall, M.D.
Clinical Specialties

Infectious Diseases , Immune Compromise , Sepsis , Immunology

Education & Training
  BS Wake Forest University 1957
  MD WFU School of Medicine 1961
Residency   Boston Med Ctr 1963
    Boston Med Ctr 1966
Internship   Boston Med Ctr 1962
Fellowship   Harvard Medical School 1968
American Association of Advancement of Science
American Association of Immunologists
American Association of University Professors
American Coll of Physicians
American Federation of Clinical Research
American Society of Clinical Investigation
Association of American Physicians
Infectious Disease Society of Am.
NPI Number



Liu TF, McCall CE. Deacetylation by SIRT1 reprograms inflammation and cancer. Genes Cancer. 2013;4(3-4):135-147.


Brudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar M.Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis. Infect Immun. 2012;80(2):602-611.



Vachharajani V, Cunningham C, Yoza B, Carson J Jr, Vachharajani TJ, McCall C.Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity (Silver Spring). 2012;20(3):498-504.


Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect Immun. 2012;80(6):2026-2034.




Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.


Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012;92(3):499-507.


Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Adoptive transfer of CD34+ cells during murine sepsis rebalances macrophage lipopolysaccharide responses. Immunol Cell Biol. 2012;90(10):925-934.



Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011;286(11):9856-9864.


Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011;35(6):604-609.



McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011;90(3):439-446.


McCall C, Bowes RC, McCall W. Objective vs. subjective measurements of sleep in depressed insomniacs: first night effect or reverse first night effect? [abstract]. Sleep. 2011;34(Suppl):A255-A256.


El Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010;285(2):1259-1271.


El Gazzar M, McCall CE. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem. 2010;285(27):20940-51.


Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010;17(6):407-416.


McCall CE, Yoza B, Liu T, El Gazzar M. Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun. 2010;2(5):395-405.


Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. J Am Coll Surg. 2010;211(3 Suppl):S51.


Chen X, Yoza BK, El Gazzar M, Hu JYQ, Cousart SL, McCall CE. RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol. 2009;16(1):104-110.


El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silence proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009;29(7):1959-1971.


Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK.Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009;31(4):376-381.



Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009;67(1):14-21.


El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE. G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem. 2008;283(47):32198-208.


McCall CE, Yoza BK. Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med. 2007;175(8):763-767.


El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR.Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111(1):36-44.


El Gazzar M, Yoza BK, Hu JY-Q, Cousart SL, McCall CE. Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. J Biol Chem. 2007;282(37):26857-64.


Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE.Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28(4):447-452.


Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang B-L. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS ONE. 2007;2(10):e1035.


Cross(mult/tnslat/inter)discip , education/training (all f, t, , health services, research/outc , immunology/allergy/inflammation , infectious diseases.