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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

Che-Ping Cheng, M.D./Ph.D.

Che-Ping Cheng, M.D./Ph.D.
Education & Training
  MD Nanjing Railway Medical University-China 1977
  PhD Wayne State University School of Medicine 1986
  WFU School of Medicine 1988
Int'L Society For Heart Research
American Association for the Advancement of Science
American Society for Biochemistry and Molecular Biology
American Federation of Clinical Research
American Heart Association
American Physiological Society
Cardiovascular Systems Dynamics Society
Heart Failure Society of America
Int'L Society Biomedical Rsrch Alcoholism


Cheng CP, Shao Q, Cheng H-J, Callahan MF. Mechanism of chronic CaMKII inhibition-caused regression of heart failure: beneficial effects on neurohormonal activation, left ventricular and cardiomyocyte contractile function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circ Res. 2013;113(4 Suppl):A035.


Cheng CP, Cheng H-J, Zhou P, Li T-K, Kitzman DW, Kritchevsky SB, Little WC.Reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase in mice deficient in beta3-adrenoreceptor: insights into the molecular mechanism of cardiac aging [abstract]. Circ Res. 2013;113(4 Suppl):A087.


Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP.Beta 3-adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2013;305(6):H923-30.


Zhou P, Cheng H-J, Cheng CP. Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation of L-type calcium current in heart failure by chronic beta3-AR deficiency: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2012;126(21 Suppl):A9675.


Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Late initiation of chronic CaMKII inhibition causes regression in rat model of progressive heart failure: insights into the underlying cellular mechanim [abstract]. Circulation. 2012;126(21 Suppl):A11401.


Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Overexpression myocardial inducible nitric oxide synthase (iNOS) exacerbates cardiac dysfunction and beta-adrenergic desensitization in rats with experimental hypothyroidism [abstract]. Circulation. 2012;126(21 Suppl):A11340.


Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP. Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Circulation. 2012;126(21 Suppl):A11645.


Cheng CP, Zhou P, Cheng H-J, Shao Q, Sane DC, Little WC. Chronic urotensin II receptor blockade causes regression of heart failure: beneficial effects on neurohormonal activation, cardiomyocyte contractile function [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circulation. 2012;126(21 Suppl):A9932.


Masutani S, Cheng H-J, Tachibana H, Little WC, Cheng C-P. Levosimendan restores the positive force-frequency relation in heart failure. Am J Physiol Heart Circ Physiol. 2011;301(2):H488-496.


Cheng CP, Zhou P, Cheng H-J. Cellular basis for angiotensin-(1-7)-induced positive modulation on cardiac contractile performance in heart failure [abstract]. J Card Fail. 2011;17(8 Suppl):S62.


Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP. Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Circulation. 2011;124(21 Suppl):A9254.


Shao Q, Cheng H-J, Callahan MF, Wong SH, Wesley DJ, Li W-M, Cheng CP.Mechanism of thyroid-hormone-deficiency-caused cardiac injury in a rat model: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Circulation. 2011;124(21 Suppl):A9149.


Cheng H-J, Shao Q, Zhang L, Callahan MF, Wagner JD, Cheng CP. Upregulation and adverse effects of cardiac beta3-adrenoreceptor-mediated inducible nitric oxide synthase (iNOS)-coupled pathway in monkeys with naturally occurring type 2 diabetes [abstract]. Circulation. 2011;124(21 Suppl):A10649.


Cheng H-J, Zhou P, Zhao W, Wajih N, Han Q-H, Little WC, Cheng CP.Upregulation of cardiac urotensin II (UII) exacerbates UII stimulation-induced negative modulation on myocyte contractile function and Ca2+ current in streptozotocin-induced diabetic rats [abstract]. Circulation. 2011;124(21 Suppl):A9259.


Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC. Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Circulation. 2011;124(21 Suppl):A12986.


Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P. Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010;34(7):1171-1181.


Cheng C-P, Han Q-H, Cheng H-J, Onishi K, Ukai T, Ohte N, Little WC. Is up-regulation of beta3-adrenergic receptor (AR) in the failing myocardium detrimental or beneficial?--Effect on chronic beta3-AR blockade in pacing-induced heart failure [abstract]. Circulation. 2010;122(21 Suppl):A17062.


Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P.Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Circulation. 2010;122(21 Suppl):A13008.


Zhou P, Cheng H-J, Zhang Z-S, Little WC, Cheng C-P. Inducible nitric oxide synthase stimulation depresses cardiomyocyte basal and beta-adrenergic response of L-type calcium current in heart failure: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2010;122(21 Suppl):A15884.


Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA. Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. J Card Fail. 2009;15(Suppl 6):S42.


Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Tang WJ, Leppla SH. Pathophysiology of anthrax. Front Biosci. 2009;14():4516-4524.


Cheng C-P, Cheng H-J, Hasegawa H, Morimoto A, Zhou P, Cross M, Little WC.Na+-H+ exchange inhibition by cariporide enhances cardiac positive inotropic and lusitropic responses to dobutamine in heart failure: assessment by pressure-volume analysis [abstract]. Circulation. 2009;120(18 Suppl):S733-S734.


Zhou P, Cheng H-J, Cross M, Little WC, Cheng C-P. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal vs heart failure [abstract]. Circulation. 2009;120(18 Suppl):S694.


Cheng C-P, Cheng H-J, Zhou P, Markert CD, Cross M, Kornegay JN, Stedman H, Childers MK. Cardiomyopathy in a canine model of Duchenne muscular dystrophy: effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation [abstract]. Circulation. 2009;120(18 Suppl):S667.


Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P. Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Circulation. 2009;120(18 Suppl):S584-S585.


Zhou P, Cheng H-J, Hasegawa H, Morimoto A, Cross M, Cheng C-P. Enhanced C-type natriuretic peptide positive modulation on cardiac performance in heart failure: effects on left ventricle and myocyte contraction, [Ca2+]i transient and Ca2+ current [abstract]. Circulation. 2009;120(18 Suppl):S820.


Aging , cardiac function , drugs/therapeutic agents pharm , molecular biology/molecular me , substance abuse.