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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

David A Ornelles, Ph.D.

David A Ornelles, Ph.D.
Associate Professor, Microbiology & ImmunologyComprehensive Cancer Center
Translational Science Institute
Cancer Biology
Institute for Regenerative Medicine
Translational Science Institute
Clinical Specialties

Acute and Chronic Leukemia , Cancer Cell Biology

Education & Training
  BS University of Hawaii-Manoa 1980
  PhD Massachusetts Institute of Technology 1987
  Howard Hughes Medical Institute 1993


Murphy AM, Besmer DM, Moerdyk-Schauwecker M, Moestl N, Ornelles DA, Mukherjee P, Grdzelishvili VZ. Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. J Virol. 2012;86(6):3073-3087.


Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012;94(16):1458-1467.


Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP.Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012;1(6):810-821.


Freedman BI, Murea M, Rocco MV, Ma L, Bowden DW, Ornelles DA, Kleiboeker S, Langefeld CD, Turner J, Divers J. JC polyoma virus interacts with apolipoprotein L1 genetic risk in African Americans with non-diabetic nephropathy [abstract]. J Am Soc Nephrol. 2012;23():178A.


Honkaniemi E, Talekar G, Huang W, Bogdanovic G, Forestier E, von Doblen U, Engvall M, Ornelles DA, Gooding LR, Gustafsson B. Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL). Br J Cancer. 2010;102(5):796-798.


Zhang Y, Huang W, Ornelles DA, Gooding LR. Modeling adenovirus latency in human lymphocyte cell lines. J Virol. 2010;84(17):8799-8810.


Garnett CT, Talekar G, Mahr JA, Huang W, Zhang Y, Ornelles DA, Gooding LR.Latent species C adenoviruses in human tonsil tissues. J Virol. 2009;83(6):2417-2428.


Thomas MA, Broughton RS, Goodrum FD, Ornelles DA. E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus. J Virol. 2009;83(6):2406-2416.




Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. J Virol. 2008;82(13):6395-6408.


Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol. 2008;181(12):8576-8584.


Hart LS, Ornelles D, Koumenis C. The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. J Biol Chem. 2007;282(9):6061-6067.


Gustafsson B, Huang W, Bogdanovic G, Gauffin F, Nordgren A, Talekar G, Ornelles DA, Gooding LR. Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia. Br J Cancer. 2007;97(7):992-994.


Cancer/oncogenesis , cell growth, differentiation,d , infectious diseases , molecular biology/molecular me.