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Molecular and Cellular Biosciences at Wake Forest University


Wake Forest University Graduate School » Molecular and Cellular Biosciences

Fang-chi Hsu, Ph.D.

Fang-chi Hsu, Ph.D.
Education & Training
  MS Natl Taiwan Univ College of Medicine-Taiwan 1995
  PhD Johns Hopkins University School of Public Health 2002
Fellowship
  Johns Hopkins University School of Public Health 2002
Memberships
American Statistical Association
American Society of Human Genetics
Biometric Society
International Chinese Statistical Association

 

Sun J, Na R, Hsu FC, Zheng SL, Wiklund F, Condreay LD, Trent JM, Xu J. Genetic score is an objective and better measurement of inherited risk of prostate cancer than family history [letter]. Eur Urol. 2013;63(3):585-587.

 

Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

 

McClain J, Hsu F, Brown E, Burke G, Carr J, Harris T, Kritchevsky S, Szklo M, Tracy R, Ding J. Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA. Obesity (Silver Spring). 2013;21(5):1056-1063.

 

Shea M, Kritchevsky SB, Hsu F-C, Nevitt MC, Kwoh C, Booth SL, Vermeer C, Loeser RF. Vitamin K status and MRI-based knee osteoarthritis characteristics in community-dwelling older adults: the Health ABC Study [abstract]. Osteoarthritis Cartilage. 2013;21():S152-S153.

 

 

Cox AJ, Hugenschmidt CE, Wang PT, Hsu FC, Kenchaiah S, Daniel K, Langefeld CD, Freedman BI, Herrington DM, Carr JJ, Stacey B, Bowden DW. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol. 2013;111(8):1152-1158.

 

Raffield LM, Cox AJ, Hsu FC, Ng MC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():95.

 

Chiu Y-F, Lee C-Y, Kao H-Y, Pan W-H, Hsu F-C. Analysis of family- and population-based samples using multiple linkage disequilibrium mapping. Ann Hum Genet. 2013;77():251-267.

 

Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229(1):155-160.

 

Hugenschmidt CE, Hsu FC, Hayasaka S, Carr JJ, Freedman BI, Nyenhuis DL, Williamson JD, Bowden DW. The influence of subclinical cardiovascular disease and related risk factors on cognition in type 2 diabetes mellitus: the DHS-Mind study. J Diabetes Complications. 2013;27(5):422-428.

 

 

 

Tao S, Wang Z, Feng J, Hsu F-C, Jin G, Kim S-T, Zhang Z, Gronberg H, Zheng LS [sic] [Zheng SL], Isaacs WB, Xu J, Sun J. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Carcinogenesis. 2012;33(3):598-603.

 

Wang X, Hsu F-C, Isom S, Walkup MP, Kritchevsky SB, Goodpaster BH, Church TS, Pahor M, Stafford RS, Nicklas BJ. Effects of a 12-month physical activity intervention on prevalence of metabolic syndrome in elderly men and women. J Gerontol A Biol Sci Med Sci. 2012;67A(4):417-424.

 

Cheng Y-C, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr, Chen F, Chen W-M, Cuisani E, Cole JW, Cortellini L, Danesh J, Hsu F-C, et al. Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?. Stroke. 2012;43(4):980-986.

 

Newcombe PJ, Reck BH, Sun J, Platek GT, Verzilli C, Kader AK, Kim S-T, Hsu F-C, Zhang Z, Zheng SL, Mooser VE, Condreay LD, Spraggs CF, Whittaker JC, Rittmaster RS, Xu J. A comparison of Bayesian and Frequentist approaches to incorporating external information for the prediction of prostate cancer risk. Genet Epidemiol. 2012;36(1):71-83.

 

Tao S, Feng J, Webster T, Jin G, Hsu F-C, Chen S-H, Kim S-T, Wang Z, Zhang Z, Zheng SL, Isaacs WB, Xu J, Sun J. Genome-wide two-locus epistasis scans in prostate cancer using two European populations. Hum Genet. 2012;131(7):1225-1234.

 

Chen SH, Ip EH, Xu J, Sun J, Hsu FC. Using graded response model for the prediction of prostate cancer risk. Hum Genet. 2012;131(8):1327-1336.

 

Brinkley TE, Hsu FC, Beavers KM, Church TS, Goodpaster BH, Stafford RS, Pahor M, Kritchevsky SB, Nicklas BJ. Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci. 2012;67(10):1099-1106.

 

Buford TW, Manini TM, Hsu F-C, Cesari M, Anton SD, Nayfield S, Stafford RS, Church TS, Pahor M, Carter CS. Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise. J Am Geriatr Soc. 2012;60(7):1244-1252.

 

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu F-C, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012;178(1):46-56.

 

 

Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F,. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet. 2012;91(4):744-753.

 

Kader AK, Sun J, Reck BH, Newcombe PJ, Kim ST, Hsu FC, D'Agostino RB Jr, Tao S, Zhang Z, Turner AR, Platek GT, Spraggs CF, Whittaker JC, Lane BR, Isaacs WB, Meyers DA, Bleecker ER, Torti FM, Trent JM, McConnell JD,. Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. Eur Urol. 2012;62(6):953-961.

 

Heffernan KS, Manini TM, Hsu FC, Blair SN, Nicklas BJ, Kritchevsky SB, Newman AB, Sutton-Tyrrell K, Church TS, Haskell WL, Fielding RA. Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study. PLoS One. 2012;7(11):e49544.

 

Sun J, Kader AK, Hsu F-C, Kim S-T, Zhu Y, Turner AR, Jin T, Zhang Z, Zheng SL, Xu J, et al. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. Prostate. 2011;71(4):421-430.

 

Matthews MM, Hsu F-C, Walkup MP, Barry LC, Patel KV, Blair SN. Depressive symptoms and physical performance in the Lifestyle Interventions and Independence for Elders Pilot study. J Am Geriatr Soc. 2011;59(3):495-500.

 

Brinkley TE, Hsu F-C, Carr JJ, Hundley WG, Bluemke DA, Polak JF, Ding J.Pericardial fat is associated with carotid stiffness in the Multi-Ethnic Study of Atherosclerosis. Nutr Metab Cardiovasc Dis. 2011;21(5):332-338.

 

Shea MK, Houston DK, Nicklas BJ, Davis CC, Hsu F-C, Tooze JA, Church TS, Kritchevsky SB. Circulating 25-hydroxyvitamin-D [25(OH)D] and inflammation in older community-dwelling adults [abstract]. FASEB J. 2011;25(Meeting Abstracts):595.2.

 

Elkhatib SD, Hsu F-C, Pemberton BL, Sale MM, Worrall BB. Sex differences in genetic associations with homocysteine in the Vitamin Intervention for Stroke Prevention (VISP) trial [abstract]. Stroke. 2011;42(3):e187.

 

Liu C, Leng I, Kritchevsky S, Ding J, Earnest C, Ferrucci L, Goodpaster B, Guralnik J, Hsu F, Lenchik L, et al. The impact of sarcopenia on the response to a physical activity intervention in older adults [abstract]. J Am Geriatr Soc. 2011;59(Suppl 1):S63.

 

Solorzano G, Chen F, Mychaleckyj JC, Chen W-M, Hsu F-C, Sale M, Worrall BB.Antihypertensive class and stroke recurrence: an analysis of the VISP trial [abstract]. Stroke. 2011;42(3):e348.

 

McAuley PA, Hsu F-C, Loman KK [sic] [Lohman KK], Carr JJ, Budoff MJ, Szklo M, Sharrett AR, Ding J. Liver attenuation, pericardial adipose tissue, obesity, and insulin resistance: the Multi-Ethnic Study of Atherosclerosis (MESA). Obesity (Silver Spring). 2011;19(9):1855-1860.

 

Tzeng J-Y, Zhang D, Pongpanich M, Smith C, McCarthy MI, Sale MM, Worrall BB, Hsu F-C, Thomas DC, Sullivan PF. Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression. Am J Hum Genet. 2011;89(2):277-288.

 

Hsu F-C, Sides EG, Mychaleckyj JC, Worrall BB, Elias GA, Liu Y, Chen W-M, Coull BM, Toole JF, Rich SS, et al. Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk. Neurology. 2011;77(16):1543-1550.

 

Soliman EZ, Ding J, Hsu F-C, Carr JJ, Polak JF, Goff DC Jr. Association between carotid-intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA). J Stroke Cerebrovasc Dis. 2010;19(1):58-65.

 

Palmer ND, Langefeld CD, Ziegler JT, Hsu F, Haffner SM, Fingerlin T, Norris JM, Chen YI, Rich SS, Bowden DW, et al. Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study. Diabetologia. 2010;53(2):281-289.

 

Xu J, Zheng SL, Isaacs SD, Wiley KE, Sun J, Kader AK, Li G, Purcell LD, Kim S-T, Hsu F-C, et al. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Proc Natl Acad Sci U S A. 2010;107(5):2136-2140.

 

Hsu F-C, Sun J, Zhu Y, Kim S-T, Jin T, Zhang Z, Wiklund F, Kader AK, Zheng SL, Xu J, et al. Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history. Cancer Epidemiol Biomarkers Prev. 2010;19(4):1083-1088.

 

Manini TM, Newman AB, Fielding R, Blair SN, Perri MG, Anton SD, Katula JA, Rejeski WJ, Kritchevsky SB, Hsu F-C, et al. Effects of exercise on mobility in obese and nonobese older adults. Obesity (Silver Spring). 2010;18(6):1168-1175.

 

Patel RK, Elias GA, Hsu F-C, Mychaleckyj JC, Chen W-M, Worrall BB, Sale MM.Investigation of recurrent stroke risk in the Vitamin Intervention for Stroke Prevention (VISP) Trial suggests different genetic influences on prevalent and incident stroke [abstract]. Stroke. 2010;41(4):E335.

 

Sale MM, Hsu F-C, Mychaleckyj JC, Rich SS, Furie KL, Worrall BB. A variant in the adenosine 2B receptor gene is associated with homocysteine levels and stroke severity in African American subjects from the Vitamin Intervention for Stroke Prevention (VISP) Trial [abstract]. Stroke. 2010;41(4):E334.

 

Howard TD, Hsu F-C, Grzywacz JG, Chen H, Quandt SA, Vallejos QM, Whalley LE, Cui W, Padilla S, Arcury TA. Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. Environ Health Perspect. 2010;118(10):1395-1399.

 

Beavers KM, Hsu F-C, Isom S, Kritchevsky SB, Church T, Goodpaster B, Pahor M, Nicklas BJ. Long-term physical activity and inflammatory biomarkers in older adults. Med Sci Sports Exerc. 2010;42(12):2189-2196.

 

Kim S-T, Cheng Y, Hsu F-C, Jin T, Kader AK, Zheng SL, Isaacs WB, Xu J, Sun J.Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic variation. Prostate. 2010;70(16):1729-1738.

 

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

 

Alley D, Hsu F, Walkup MP, Shardell M, Pahor M, Studenski S, Guralnik J, Harris T.Effect of physical activity on hospitalization-associated functional decline: the Life Pilot Study [abstract]. Gerontologist. 2010;50(Suppl 1):439.

 

Hsu F-C, Rejeski WJ, Ip EH, Katula JA, Fielding R, Jette AM, Studenski SA, Blair SN, Miller ME. Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Health Qual Life Outcomes. 2010;8():115.

 

Robbins ME, Payne V, Tommasi E, Diz DI, Hsu F-C, Brown WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2009;73(2):499-505.

 

Sun J, Zheng SL, Li G, Kim S-T, Zhu Y, Zhang Z, Hsu F-C, Turner AR, Liu W, Kim JW, Xu J, Chang B-L, et al. Sequence variants at 22q13 are associated with prostate cancer risk. Cancer Res. 2009;69(1):10-15.

 

Zheng SL, Sun J, Gao Z, Purcell LD, Hsu F-C, Zhu Y, Turner AR, Adams TS, Liu W, Chang B-L, Xu J, et al. Genetic variants and family history predict prostate cancer similar to prostate-specific antigen. Clin Cancer Res. 2009;15(3):1105-1111.

 

Hsu F-C, Kritchevsky SB, Liu Y, Kanaya A, Newman AB, Perry SE, Visser M, Pahor M, Harris TB, Nicklas BJ. Association between inflammatory components and physical function in the Health, Aging, and Body Composition Study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci. 2009;64(5):581-589.

 

Wiklund F, Zheng SL, Sun J, Adami H-O, Lilja H, Hsu F-C, Stattin P, Cramer SD, Chang B-L, Xu J, et al. Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancer. Prostate. 2009;69(4):419-427.

 

Chang B-L, Cramer SD, Sun J, Smith S, Pruett K, Romero LM, Zhu Y, Zhang Z, Hsu F-C, Turner AR, Liu W, Kim JW, Zheng SL, Xu J, et al. Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk. Hum Mol Genet. 2009;18(7):1368-1375.

 

Hsu F-C, Sun J, Purcell LD, Gao Z, Zhu Y, Kim S-T, Zhang Z, Liu W, Chang B-L, Xu J, Zheng SL, et al. A novel prostate cancer susceptibility locus at 19q13. Cancer Res. 2009;69(7):2720-2723.

 

Brinkley TE, Hsu F, Hawkins GA, Kritchevsky SB, Pahor M, Nicklas BJ. The ACE I/D genotype and improvement in 400-meter walk performance with exercise training in the Lifestyle Intervention and Independence for Elders Pilot (LIFE-P) [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S123.

 

Rasmussen-Torvik LJ, Pankow JS, Wassel CL, Goodarzi MO, Guo X, Shea SJ, Hsu F-C, Bowden DW. Association of ADIPOQ, TNFA, and TNFRSF1A single-nucleotide polymorphisms with insulin resistance; the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Circulation. 2009;119(10):e328.

 

Zheng SL, Sun J, Smith S, Pruett K, Kim S-T, Zhu Y, Zhang Z, Hsu F-C, Turner AR, Liu W, Kim JW, Chang B-L, Xu J, et al. Two independent prostate cancer risk-associated Loci at 11q13. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1815-1820.

 

Xu J, Sun J, Kader AK, Lindstrom S, Wiklund F, Hsu F-C, Kim S-T, Johansson J-E, Zheng SL, Platz EA, et al. Estimation of absolute risk for prostate cancer from blood DNA [abstract]. J Urol. 2009;181(4 Suppl):643.

 

Xu J, Kibel AS, Turner AR, Pruett K, Zheng SL, Sun J, Kim S-T, Hsu F-C, Torti FM, Chang B-L, et al. Prostate cancer risk associated loci in African Americans. Cancer Epidemiol Biomarkers Prev. 2009;18(7):2145-2149.

 

Ding J, Hsu F-C, Harris TB, Liu Y, Kritchevsky SB, Szklo M, Ouyang P, Espeland MA, Lohman KK, Carr JJ, et al. The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr. 2009;90(3):499-504.

 

Xu J, Sun J, Kader AK, Lindstrom S, Wiklund F, Hsu F-C, Johansson J-E, Zheng SL, Thomas G, Hayes RB, et al. Estimation of absolute risk for prostate cancer using genetic markers and family history. Prostate. 2009;69(14):1565-1572.

 

Ramanan S, Kooshki M, Zhao W, Hsu F-C, Riddle DR, Robbins ME. The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Int J Radiat Oncol Biol Phys. 2009;75(3):870-877.

 

Carr JJ, Register TC, Hsu F-C, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Wagenknecht LE, Freedman BI, et al. Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the Diabetes Heart Study. Bone. 2008;42(1):43-52.

 

Saran AM, Hsu F-C, Lohman KK, Carr JJ, Bowden DW, Wagenknecht LE, Freedman BI. Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study. Am J Nephrol. 2008;28(3):366-371.

 

Zheng SL, Sun J, Smith S, Li G, Hsu F-C, Zhu Y, Kader AK, Turner AR, Liu W, Bleecker ER, Meyers DA, Chang B-L, Xu J, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358(9):910-919.

 

Sale MM, Furie KL, Hsu F-C, Mychaleckyj JC, Sides EG, Howard TD, Worrall BB, Liu Y, Coull BM, Toole JF, et al. Multiple variants in the transcobalamin 2 and cystathionine beta-synthase genes are associated with homocysteine levels in subjects from the Vitamin Intervention for Stroke Prevention (VISP) trial [abstract]. Stroke. 2008;39(2):630.

 

Chen S-H, Sun J, Dimitrov L, Turner AR, Adams TS, Meyers DA, Chang B-L, Zheng SL, Xu J, Hsu F-C, et al. A support vector machine approach for detecting gene-gene interaction. Genet Epidemiol. 2008;32(2):152-167.

 

Sun J, Purcell L, Gao Z, Isaacs SD, Wiley KE, Hsu F-C, Liu W, Xu J, Chang B-L, Zheng SL, et al. Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans. Prostate. 2008;68(7):691-697.

 

Hsu F-C, Lindstrom S, Sun J, Wiklund F, Turner AR, Liu W, Kim JW, Chang B-l, Xu J, Zheng SL, et al. A multigenic approach to evaluating prostate cancer risk in a systematic replication study. Cancer Genet Cytogenet. 2008;183(2):94-98.

 

Nestadt G, Costa PT Jr, Hsu F-C, Samuels J, Bienvenu OJ, Eaton WW. The relationship between the five-factor model and latent Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder dimensions. Compr Psychiatry. 2008;49(1):98-105.

 

Ding J, Kritchevsky S, Hsu F-C, Harris T, Burke G, Szklo M, Criqui M, Allison M, Schreiner P, Carr J, et al. Nonsubcutaneous adiposity and relation to metabolic abnormalities: the Multi-Ethnic Study of Atherosclerosis [abstract]. Circulation. 2008;117(11):e238.

 

Foy CG, Hsu F-C, Haffner SM, Norris JM, Rotter JI, Henkin LF, Bryer-Ash M, Chen Y-DI, Wagenknecht LE. Visceral fat and prevalence of hypertension among African Americans and Hispanic Americans: findings from the IRAS family study. Am J Hypertens. 2008;21(8):910-916.

 

Ding J, Kritchevsky SB, Hsu F-C, Harris TB, Burke GL, Detrano RC, Szklo M, Criqui MH, Allison M, Carr JJ, et al. Association between non-subcutaneous adiposity and calcified coronary plaque: a substudy of the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2008;88(3):645-650.

 

Sun J, Zheng SL, Purcell LD, Gao Z, Hsu F-C, Kim S-T, Liu W, Zhu Y, Dimitrov L, Sun J, Li T, Turner AR, Adams TS, Chang B-L, Xu J, et al. Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet. 2008;40(10):1153-1155.

 

Xu J, Sun J, Li G, Zhu Y, Hsu F-C, Turner AR, Adams TS, Liu W, Chang B, Zheng S, et al. Association of prostate cancer risk variants with clinicopathologic characteristics of the disease. Clin Cancer Res. 2008;14(18):5819-5824.

 

Ramanan S, Kooshki M, Zhao W, Hsu F-C, Robbins ME. PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic Biol Med. 2008;45(12):1695-1704.

 

Nicklas BJ, Hsu F-C, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, Pahor M. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008;56(11):2045-2052.

 

Robbins M, Payne V, Diz D, Hsu FC, Zhao WL. Chronic inhibition of the renin-angiotensin system prevents radiation-induced cognitive impairment in the adult male rat [abstract]. Neuro Oncol. 2008;10(5):851.

 

Bielinski SJ, Pankow JS, Hsu F-C, Adar SD, Jenny NS, Bowden DW, Wasserman BA, Arnett D. ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2008;201(2):339-344.

 

Brinkley TE, Carr JJ, Hundley WG, Hsu FC, Bluemke DA, Polak JF, Ding JZ.Increased pericardial fat is associated with carotid artery stiffness: the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Circulation. 2008;118(18 Suppl 2):S1153.

 

Nicklas B, Hsu F, Church T, Kritchevsky S, Pahor M. Association between changes in inflammation and risk for mobility disability [abstract]. Gerontologist. 2008;48(Special Issue 3):198.



 

RESEARCH:
Dr. Hsu's methodological research interests are in the development of statistical methods in genetic epidemiology and longitudinal data. Specifically, she has developed a statistical method to directly localize susceptibility genes via multipoint linkage disequilibrium mapping. Her current collaborative research focuses on the mapping of genes for complex traits including type II diabetes, stroke, and prostate cancer. Also she has been involved in few aging studies where she applies the statistical methods in observational and clinical trial studies.