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Molecular and Cellular Biosciences at Wake Forest University


Wake Forest University Graduate School » Molecular and Cellular Biosciences

Greg Kucera, Ph.D.

Greg Kucera, Ph.D.
Education & Training
  BS Davidson College 1982
  PhD Wake Forest University 1987
Fellowship   University of Vermont 1990

 

Ding S, Qiao X, Kucera GL, Bierbach U. Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer. Chem Commun (Camb). 2013;49(24):2415-2417.

Ding S, Qiao X, Suryadi J, Marrs GS, Kucera GL, Bierbach U. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents. Angew Chem Int Ed Engl. 2013;52(12):3350-3354.

Morris-Natschke SL, Fleming RA, Kucera GL, inventors; Wake Forest University Health Sciences, assignee. Novel phospholipid conjugates double-targeted HIV. United States Patent US 8,138,200. 2012 Mar 20. 2012;():.

Qiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach U.Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Metallomics. 2012;4(7):645-652.



Kucera L, Ishaq KS, Morris-Natschke SL, Fleming RA, Kucera GL, inventors; Wake Forest University Health Sciences, assignee. Compositions and methods for double-targeting virus infections and targeting cancer cells. Japan patent JP 5031162; 2012 July 6. 2012;():.

Pickard AJ, West TK, Kucera GL, Bierbach U. Biomedical applications of targeting platinum conjugates to DNA secondary structural motifs [abstract]. Abstr Pap Am Chem Soc. 2011;241():161-INOR.

Smyre CL, Saluta G, Kute TE, Kucera GL, Bierbach U. Inhibition of DNA synthesis by a platinum-acridine hybrid agent leads to potent cell kill in nonsmall cell lung cancer. ACS Med Chem Lett. 2011;2(11):870-874.

Graham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach U. Unusual reactivity of a potent platinum-acridine hybrid antitumor agent. ACS Med Chem Lett. 2011;2(9):687-691.

Rao L, West TK, Saluta G, Kucera GL, Bierbach U. Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. Chem Res Toxicol. 2010;23(7):1148-1150.

Pickin KA, Alexander RL, Morrow CS, Morris-Natschke SL, Ishaq KS, Fleming RA, Kucera GL. Phospholipid/deoxycytidine analogue prodrugs for the treatment of cancer. J Drug Del Sci Tech. 2009;19(1):31-36.


Kheradi AR, Saluta G, Kucera GL, Day CS, Bierbach U. Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Bioorg Med Chem Lett. 2009;19(13):3423-3425.

Kucera L, Fleming R, Ishaq K, Kucera G, Morris-Natschke S, inventors; Wake Forest University Health Sciences, assignee. Compositions and methods for targeting cancer cells. United States patent US 7,638,528. 2009 Dec 29. 2009;():.


Ma Z, Saluta G, Kucera GL, Bierbach U. Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. Bioorg Med Chem Lett. 2008;18(13):3799-3801.

Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U. A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. J Med Chem. 2008;51(23):7574-7580.


Park G, Tomlinson JT, Misenheimer JA, Kucera GL, Manderville RA. Photo-induced cytotoxicity of prodigiosin analogues. Bull Korean Chem Soc. 2007;28(1):49-52.

Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U. Effect of the diamine nonleaving group in platinum--acridinylthiourea conjugates on DNA damage and cytotoxicity. J Med Chem. 2007;50(9):2259-2263.

Lentz SS, Miller BE, Kucera GL, Levine EA. Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma. Gynecol Oncol. 2007;106(1):207-210.

Kucera L, Ishaq K, Morris-Natsche S, Kucera G, Fleming R, inventors; Wake Forest University Health Sciences, assignee. Compositions and methods for targeting cancer cells. Unites States patent US 7,309,696. 2007 Dec 18. 2007;():.

Tomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RA.Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue. Org Lett. 2006;8(21):4951-4954.

 

Cancer/oncogenesis , drugs/therapeutic agents pharm.