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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

J. Jason Hoth, M.D./PhD

J. Jason Hoth, M.D./PhD


PhD, Molecular Medicine and Translational Science, 2009
Wake Forest University School of Medicine, Winston-Salem, NC

MD, Louisiana State University Medical School (1996)       

BS, Louisiana State University (1992)
July 1, 2001-June 30, 2002  Trauma/Critical Care Fellow
University of Louisville School of Medicine, Louisville, KY

July 1, 1996-June 30, 2001  General Surgery Residency
Wake Forest Baptist Medical Center, Winston-Salem, NC.

August 1, 2003-present  
Assistant Professor of Surgery
Department of Surgery
Wake Forest University Health Sciences, Winston-Salem, NC


Honors and Awards:

1996             Alpha Omega Alpha Medical Honorary Society
2002             Raymond H. Alexander, MD, Resident Paper Competition
2004             American Association for the Surgery of Trauma Research and Education Foundation Scholarship
2007             American Lung Association Biomedical Research Grant
2007-2009   American College of Surgeons C. James Carrico Faculty Research Scholarship


Weaver AA, Danelson KA, Armstrong EG, Hoth JJ, Stitzel JD. Investigation of pulmonary contusion extent and its correlation to crash, occupant, and injury characteristics in motor vehicle crashes. Accid Anal Prev. 2013;50():223-233.


Hoth JJ. A grim picture, indeed [editorial]. Crit Care Med. 2013;41(3):923-324.




Becher RD, Meredith JW, Chang MC, Hoth JJ, Beard HR, Miller PR. Creation and implementation of an emergency general surgery registry modeled after the National Trauma Data Bank. J Am Coll Surg. 2012;214(2):156-163.


Meredith JW, Hoth JJ. Thoracic trauma In: Fischer JE, Jones DB, Pomposelli FB, Upchurch GR, Klimberg VS, Schwaitzberg SD, Bland KI, eds. Fischer's mastery of surgery, vol 1. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2012: 675-687.


Becher RD, Hoth JJ, Miller PR, Meredith JW, Chang MC. Systemic inflammation worsens outcomes in emergency surgical patients. J Trauma. 2012;72(5):1140-1149.



Becher RD, Colonna AL, Enniss TM, Weaver AA, Crane DK, Martin RS, Mowery NT, Miller PR, Stitzel JD, Hoth JJ. An innovative approach to predict the development of adult respiratory distress syndrome in patients with blunt trauma. J Trauma Acute Care Surg. 2012;73(5):1229-1235.


Becher RD, Hoth JJ, Rebo JJ, Kendall JL, Miller PR. Locally derived versus guideline-based approach to treatment of hospital-acquired pneumonia in the trauma intensive care unit. Surg Infect (Larchmt). 2012;13(6):352-359.


Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H III, Hoth JJ, Mikkelsen ME, Gentile NT, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011;183(4):462-470.


Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011;35(6):604-609.


Mowery NT, Dougherty SD, Hildreth AN, Holmes JH IV, Chang MC, Martin RS, Hoth JJ, Meredith JW, Miller PR. Emergency department length of stay is an independent predictor of hospital mortality in trauma activation patients. J Trauma. 2011;70(6):1317-1325.



Gayzik FS, Hoth JJ, Stitzel JD. Finite element-based injury metrics for pulmonary contusion via concurrent model optimization. Biomech Model Mechanobiol. 2011;10(4):505-520.


Becher RD, Hoth JJ, Neff LP, Rebo JJ, Martin RS, Miller PR. Multidrug-resistant pathogens and pneumonia: comparing the trauma and surgical intensive care units. Surg Infect (Larchmt). 2011;12(4):267-272.


Danelson KA, Gayzik FS, Stern AR, Hoth JJ, Stitzel JD. Design, development, and analysis of a surrogate for pulmonary injury prediction. Ann Biomed Eng. 2011;39(10):2560-2567.


Hildreth AN, Enniss T, Martin RS, Miller PR, Mitten-Long D, Gasaway J, Chang MC, Hoth JJ, Mowery NT, Meredith JW, et al. Surgical intensive care unit mobility is increased after institution of a computerized mobility order set and intensive care unit mobility protocol: a prospective cohort analysis. Am Surg. 2010;76(8):818-822.


Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. J Am Coll Surg. 2010;211(3 Suppl):S51.


Gayzik FS, Martin RS, Gabler HC, Hoth JJ, Duma SM, Meredith JW, Stitzel JD.Characterization of crash-induced thoracic loading resulting in pulmonary contusion. J Trauma. 2009;66(3):840-849.


Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK.Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009;31(4):376-381.


Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009;67(1):14-21.


Daly M, Miller PR, Carr JJ, Gayzik FS, Hoth JJ, Meredith JW, Stitzel JD. Traumatic pulmonary pathology measured with computed tomography and a semiautomated analytic method. Clin Imaging. 2008;32(5):346-354.


Gayzik FS, Hoth JJ, Stitzel JD. Quantitative histology of contused lung tissue with comparison to computed tomography. Biomed Sci Instrum. 2008;44():225-230.


Meredith JW, Hoth JJ. Thoracic trauma: when and how to intervene. Surg Clin North Am. 2007;87(1):95-118.


Danelson KA, Hoth JJ, Miller PR, Stitzel JD. A semi-automated approach for measuring splenic injury using computed tomography. Biomed Sci Instrum. 2007;43():13-17.



Martin RS, Smith JS, Hoth JJ, Miller PR, Meredith JW, Chang MC. Increased insulin requirements are associated with pneumonia after severe injury. J Trauma. 2007;63(2):358-364.


Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE.Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28(4):447-452.


Turina M, Hoth JJ, Turpen RM, Scott MJ, Cheadle WG. Alveolar interleukin-10 regulates neutrophil apoptosis in severely traumatized patients. J Trauma. 2007;63(4):733-739.



My interests include trauma/critical care and emergency general surgery.  I am in my fourth year of graduate school at Wake Forest School of Medicine and have an active laboratory.  My basic science research interests include the inflammatory response to injury, neutrophil activation and trafficking, and Toll-like Receptor-4.  Clinical research interests include pulmonary contusion, nosocomial pneumonia, and posttraumatic empyema.