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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

Leanne Groban, M.D.

Leanne Groban, M.D.
Clinical Specialties Cardiothoracic Anesthesia , Adult Cardiothoracic Anesthesia , Major Vascular Anesthesia , Myocardial Protection , Cardiac Aging , Diastolic Dysfunction Education & Training BS University of Wisconsin-Madison 1982 MS University of Wisconsin-Milwaukee 1988 MD Medical College of Wisconsin 1992 Residency Anesthesiology North Carolina Baptist Hospital 1996 Internship Anesthesiology St Luke's Hosp 1993 Fellowship WFU School of Medicine 1997 Memberships Alpha Omega Alpha


Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.


Kim S, Edwards A, Rustowicz L, Roach C, Marsh A, Rejeski J, Kritchevsky S, Groban L. Do sex differences in preoperative mobility, nutrition, and frailty status predict length of hospital stay among older noncardiac surgical patients? [abstract]. J Am Geriatr Soc. 2013;61(Suppl 1):S127.


Laxton M, Porter J, Carter J, Roy R, Lagoo-Deenadayalan S, Groban L.Perioperative care of older patients: viewpoints from anesthesia and surgical residents [abstract]. In: Abstracts of the 39th Annual Meeting & Educational Leadership Conference of the Association for Gerontology in Higher Education; 2013 Feb 28 - Mar 3; St. Petersburg (FL). 2013;():97.


Jessup JA, Wang H, Macnamara LM, Presley TD, Kim-Shapiro DB, Zhang L, Chen AF, Groban L. Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats. Menopause. 2013;20(8):860-868.


Carter CS, Marzetti E, Leeuwenburgh C, Manini T, Foster TC, Groban L, Scarpace PJ, Morgan D. Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia. J Gerontol A Biol Sci Med Sci. 2012;67(1):17-27.


Wang H, Jessup JA, Lin MS, Chagas C, Lindsey SH, Groban L. Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats. Cardiovasc Res. 2012;94(1):96-104.


Groban L, Lindsey S, Wang H, Lin MS [sic] [Lin MR], Kassik KA, Machado FS, Carter CS. Differential effects of late-life initiation of low-dose enalapril and losartan on diastolic function in senescent Fischer 344 x Brown Norway male rats. Age (Dordr). 2012;34(4):831-843.


Groban L, Wang H, Machado FSM, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI.Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012;1(1):49-58.


Delo DM, Guan X, Wang Z, Groban L, Callahan M, Smith T, Sane DC, Payne RM, Atala A, Soker S. Calcification after myocardial infarction is independent of amniotic fluid stem cell injection. Cardiovasc Pathol. 2011;20(2):e69-e78.


Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM. Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. J Gerontol A Biol Sci Med Sci. 2011;66(5):521-533.


Royster RL, Groban L, Grosshans DW, Jones-Haywood M-M, Slaughter TF.Cardiovascular pharmacology In: Kaplan JA, Reich DL, Savino JS, eds. Kaplan's cardiac anesthesia: the echo era. 6th ed. St. Louis (MO): Saunders/Elsevier;2011: 235-295.


Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm IGF Res. 2011;21(2):81-88.


Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, Chappell MC, Wang H, Groban L. Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause. 2011;18(6):698-708.


Schafer AM, Rains JC, Penzien DB, Groban L, Smitherman TA, Houle TT. Direct costs of preventive headache treatments: comparison of behavioral and pharmacologic approaches. Headache. 2011;51(6):985-991.


Jessup JA, Zhang L, Presley TD, Kim-Shapiro DB, Wang H, Chen AF, Groban L.Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats. Endocrinology. 2011;152(6):2428-2436.


Whelan DM, Groban L. [Pulmonary arterial catheters] [Spanish] In: Rodriguez Villar S, ed. [Critical care protocols] [Spanish]. Madrid (Spain): Marban Libros;2011: 335-340.


Whelan DM, Groban L. [Arterial cannulation] [Spanish] In: Rodriguez Villar S, ed. [Critical care protocols] [Spanish]. Madrid (Spain): Marban Libros;2011: 331-334.


Whelan DM, Groban L. [Central venous access] [Spanish] In: Rodriguez Villar S, ed. [Critical care protocols] [Spanish]. Madrid (Spain): Marban Libros;2011: 321-324.


Kitzman DW, Groban L. Exercise intolerance. Cardiol Clin. 2011;29(3):461-477.


Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.


Diz DI, Garcia-Espinosa MA, Shaltout HA, Olson J, Bourland JD, Groban L.Correlation of the brain medullary metabolites N-acetyl aspartic acid and N-acetyl aspartyl glutamate with the age related decline in sensitivity for baroreflex control of heart rate in humans [abstract]. Hypertension. 2011;58(5):e116.


Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.


Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.


Groban L, Sanders DM, Houle TT, Antonio BL, Ntuen EC, Zvara DA, Kon ND, Kincaid EH. Prognostic value of tissue Doppler-derived E/e' on early morbid events after cardiac surgery. Echocardiography. 2010;27(2):131-138.


Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-693.


Groban L, Kitzman DW. Diastolic function: a barometer for cardiovascular risk? [editorial]. Anesthesiology. 2010;112(6):1303-1306.


Groban L, Jessup J, Register T. Early estrogen replacement prevents lusitropic impairment following ovariectomy in middle-aged cynomolgus monkeys [abstract]. J Am Coll Cardiol. 2010;55(10A):A38.


Brock MF, Grace BE, Morley B, Hillegass G, Houle TT, Groban L. Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug?. J Clin Anesth. 2010;22(7):505-509.


Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats. PLoS ONE. 2010;5(11):e15433.


Dudley M, Groban L. Cardiovascular changes in the elderly and their anesthetic implications [CME]. Curr Rev Clin Anesth. 2009;29(22):261-276.


Petersen RP, Heflin MT, Groban L, Lagoo-Deenadayalan SA. Surgery residents desire more training in geriatric care [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S111-S112.



Groban L, Butterworth J. Fentanyl: destiny or devil? [editorial]. Anesth Analg. 2009;109(2):301-302.


Groban L, Lin MR, Jessup JA, Chappell MC, Brunso-Bechtold JK. GH repletion increases intracardiac Ang-1-7/ACE2 and restores diastolic function in aged male BNF344 rats [abstract]. J Card Fail. 2009;15(6 Suppl 1):S33-S34.


Jessup JA, Lindsey SH, Chappell MC, Groban L. GPR30 receptor activation improves cardiac function in intact female mRen2.Lewis rats [abstract]. J Card Fail. 2009;15(6 Suppl 1):S75.


Sanders D, Dudley M, Groban L. Diastolic dysfunction, cardiovascular aging, and the anesthesiologist. Anesthesiol Clin. 2009;27(3):497-517.



Groban L, Yamaleyeva LM, Westwood BM, Houle TT, Lin M, Kitzman DW, Chappell MC. Progressive diastolic dysfunction in the female mRen(2).Lewis rat: influence of salt and ovarian hormones. J Gerontol A Biol Sci Med Sci. 2008;63(1):3-11.


Kitzman DW, Groban L. Exercise intolerance. Heart Fail Clin. 2008;4(1):99-115.


Marzetti E, Groban L, Wohlgemuth SE, Lees HA, Lin M, Jobe H, Giovannini S, Leeuwenburgh C, Carter CS. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol. 2008;294(2):R558-R567.



Diz DI, Varagic J, Groban L. Aging and the brain renin-angiotensin system: relevance to age-related decline in cardiac function. Future Cardiol. 2008;4(3):237-245.


Groban L, Dolinski SY. Vascular procedures In: Silverstein JH, Rooke GA, Reves JG, McLeskey CH, eds. Geriatric anesthesiology. 2nd ed. New York: Springer;2008: 398-415.


Delo DM, Wang Z, Shaffer R, Guan X, Neshat S, Smith T, Callahan M, Groban L, Atala A, Soker S. Effects of human amniotic fluid derived stem cells on cardiac function after myocardial infarction [abstract]. Tissue Eng Part A. 2008;14(5):844.


Royster RL, Butterworth JF IV, Groban L, Slaughter TF, Zvara DA.Cardiovascular pharmacology In: Kaplan JA, ed. Essentials of cardiac anesthesia. Philadelphia: Saunders/Elsevier;2008: 118-163.


Groban L, Jobe H, Lin M, Houle T, Kitzman DA, Sonntag W. Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats. J Gerontol A Biol Sci Med Sci. 2008;63(9):911-920.


Sanders D, Houle T, Kon N, Zvara D, Groban L. Diastolic dysfunction predicts adverse outcome after cardiac surgery [abstract]. Anesthesiology. 2008;109():Abstr 1592.


Trask AJ, Groban L, Varagic J, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 aggravates cardiac hypertrophy in Ren-2 hypertensive rats [abstract]. Hypertension. 2008;52(4):e126.


Jessup JA, Westwood BM, Chappell MC, Groban L. Combination renin angiotensin system improves ventricular lusitropy without affecting cardiac fibrosis or cardiac RAS in the hypertensive mRen2.Lewis rat [abstract]. Circ Res. 2008;103(5):e48-e49.


Aging, genetics/genome, hypertension, nutrition, transgenics, women's health issues.