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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

Maggie Ng, M.D.

Maggie Ng, M.D.

Associate Professor, Center for Genomics and Personalized Medicine Research Center for Diabetes Research
Center for Genomics and Personalized Medicine Research

Education & Training
PhD The Chinese University of Hong Kong 1997
Fellowship The Chinese University of Hong Kong 1999

Memberships
American Society of Human Genetics

 

Ng MCY, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD,.Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Diabetes. 2013;62(3):965-976.

 

Dillon LW, Pierce LC, Ng MCY, Wang Y-H. Role of DNA secondary structures in fragile site breakage along human chromosome 10. Hum Mol Genet. 2013;22(7):1443-1456.

 

Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45(6):690-696.

 

Ma RC, Hu C, Tam CH, Zhang R, Kwan P, Leung TF, Thomas GN, Go MJ, Hara K, Sim X, Ho JS, Wang C, Li H, Lu L, Wang Y, Li JW, Wang Y, Lam VK, Wang J, Yu W, Kim YJ, Ng DP, Fujita H, Panoutsopoulou K, Day-Williams AG,. Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia. 2013;56(6):1291-1305.

 

Raffield LM, Cox AJ, Hsu FC, Ng MC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():95.

 

Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229(1):155-160.

 

Ng MCY, Hester JM, Wing MR, Li J, Xu J, Hicks PJ, Roh BH, Lu L, Divers J, Langefeld CD, Freedman BI, Palmer ND, Bowden DW. Genome-wide association of BMI in African Americans. Obesity (Silver Spring). 2012;20(3):622-627.

 

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Lu L, Ziegler JT, Divers J, Ng MCY, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE. 2012;7(1):e29202.

 

Cooke JN, Ng MCY, Palmer ND, An SS, Hester JM, Freedman BI, Langefeld CD, Bowden DW. Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care. 2012;35(2):287-292.

 

Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MCY. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465-473.

 

Cooke JN, Bostrom MA, Hicks PJ, Ng MCY, Hellwege JN, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol Dial Transplant. 2012;27(4):1505-1511.

 

 

Bostrom MA, Perlegas P, Lu L, Hicks PJ, Hawkins G, Ng MC, Langefeld CD, Freedman BI, Bowden DW. Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease. Am J Nephrol. 2012;36(3):252-260.

 

Liu CT, Ng MCY, Rybin D, Adeyemo A, Bielinski SJ, Boerwinkle E, Borecki I, Cade B, Chen YDI, Djousse L, Fornage M, Goodarzi MO, Grant SFA, Guo X, Harris T, Kabagambe E, Kizer JR, Liu Y, Lunetta KL, Mukamal K, Nettleton JA,.Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource. Diabetologia. 2012;55(11):2970-2984.

 

McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MCY, Divers J, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2011;79(5):563-572.

 

Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MCY, Bowden DW. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes. 2011;60(2):662-668.

 

Zhou J-W, Tsui SKW, Ng MCY, Geng H, Li S-K, So W-Y, Ma RC, Wang Y, Tao Q, Chen Z-Y, et al. Apolipoprotein M gene (APOM) polymorphism modifies metabolic and disease traits in type 2 diabetes. PLoS ONE. 2011;6(2):e17324.

 

 

 

Hester J, Li J, Hicks P, Langefeld C, Freedman B, Bowden D, Ng M. Implication of European-derived adiposity loci in African Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

 

Ng MCY, Sajuthi S, Cupples A, Divers J, Dupuis J, Fornage M, Kao L, Larkin E, Freedman B, Bowden DW, et al. Genetic ancestry and population structure of geographically separated African American populations [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

 

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic risk assessment of type 2 diabetes associated polymorphisms in African-Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

 

Geng H, Law PPY, Ng MCY, Li T, Liang L-Y, Ge T-F, Wong K-B, Liang C, Ma RC, So W-Y, Chan JCN, Ho Y-Y. APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk. PLoS ONE. 2011;6(10):e24669.

 

Ng MCY, Tam CHT, So WY, Ho JSK, Chan AW, Lee HM, Wang Y, Lam VKL, Chan JCN, Ma RCW. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab. 2010;95(5):2418-2425.

 

Hu C, Wang C, Zhang R, Ng MC, Bao Y, Wang C, So WY, Ma RC, Ma X, Chan JC, et al. Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population. Diabetologia. 2010;53(2):290-298.

 

Tam CH, Lam VK, So WY, Ma RC, Chan JC, Ng MC. Genome-wide linkage scan for factors of metabolic syndrome in a Chinese population. BMC Genet. 2010;11():article 14.

 

Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MCY, Lu L, Langefeld CD, Freedman BI, Bowden DW. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics. 2010;96(4):211-219.

 

Mong JLY, Ng MCY, Guldan GS, Tam CHT, Lee HM, Ma RCW, So WY, Wong GWK, Kong APS, Chan JCN, et al. Associations of the growth hormone receptor (GHR) gene polymorphisms with adiposity and IGF-I activity in adolescents. Clin Endocrinol. 2010;73(3):313-322.

 

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

 

Mcdonough CW, Allred ND, Hicks PJ, Bostrom MA, Lu L, Ng M, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome wide association study for diabetic nephropathy genes in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

 

Bostrom MA, Hicks PJ, Lu L, Ng M, Langefeld CD, Freedman BI, Bowden DW.Sequencing of alpha-actinin-4 to identify variants associated with non-diabetic end-stage renal disease (ESRD) in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

 

Cooke JN, Bostrom MA, Hicks PJ, Ng M, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):731A.

 

Ng MCY, Lam VKL, Tam CHT, Chan AWH, So W-Y, Ma RCW, Zee BCY, Waye MMY, Mak WW, Hu C, et al. Association of the POU class 2 homeobox 1 gene (POU2F1) with susceptibility to Type 2 diabetes in Chinese populations. Diabet Med. 2010;27(12):1443-1449.

 

 

Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng MCY, Hirota Y, Mori H, et al. Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet. 2009;54(4):236-241.

 

Leung TF, Sy HY, Ng MCY, Chan IH, Wong GW, Tang NL, Waye MM, Lam CW.Asthma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy. 2009;64(4):621-628.

 

Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinhorsdottir V, Ng MCY, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009;41(3):342-347.

 

Wing MR, Ziegler J, Langefeld CD, Ng MCY, Haffner SM, Norris JM, Goodarzi MO, Bowden DW. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet. 2009;125(5-6):615-626.

 

Kawai T, Ng MCY, Hayes MG, Yoshiuchi I, Tsuchiya T, Robertson H, Cox NJ, Polonsky KS, Bell GI, Ehrmann DA. Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes Res Clin Pract. 2009;86(3):186-192.

 

Hester JM, Palmer ND, Ng MCY, Adeyemo A, Rotimi C, Freedman BI, Bowden DW.Comprehensive genetic evaluation of variation at the TCF7L2 locus in African Americans [abstract]. Diabetes. 2009;58(Suppl 1):A304.

 

Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njolstad I, Ng MCY, et al. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat Genet. 2009;41(8):876-878.

 

Leung TF, Li CY, Kong APS, Chan IHS, Ng MCY, Chan MHM, So WY, Wong GWK, Lam CWK, Chan JCN. PTGDR is not a major candidate gene for asthma and atopy in Chinese children. Pediatr Allergy Immunol. 2009;20(6):556-562.

 

Mong JLY, Ng MCY, Guldan GS, Tam CHT, Lee HM, Ma RCW, So WY, Wong GWK, Kong APS, Chan JCN, et al. Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents. Int J Obes. 2009;33(12):1446-1453.

 

Song XY, Lee SY, Ma RCW, So WY, Cai JH, Tam C, Lam V, Ying W, Ng MCY, Chan JCN. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. Diabetologia. 2009;52(8):1543-1553.

 

diabetes, genetics/genome, metabolism, minority health issues