Page not found

Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

Mark Chappell, Ph.D.

Mark Chappell, Ph.D.

Education & Training

  • B.A., American University , 1983
  • Ph.D., Cleveland State University , 1993
  • Fellowship, Cardiovascular Disease, WFU School of Medicine, 1996


  • Western Nc Chpt Soc For Neuros
  • Am Soc Biochem Molecular Bio
  • Am Heart Association
  • Am Physiological Society
  • Council For High Blood Pressure
  • Endocrine Society




Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44(C):25-31.


Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. FASEB J. 2013;27(Meeting Abstracts):1107.12.


Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Reduction in central mitochondrial ROS improves cardiovagal baroreflex function independent of blood pressure in (mRen2)27 rats [abstract]. FASEB J. 2013;27(Meeting Abstracts):890.4.


Chen K, Bi J, Su Y, Figueroa J, Chappell M, Rose J. Gender affects responses of renal ACE and ACE2 activity to unilateral nephrectomy [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):335A.


Chen K, Bi J, Figueroa J, Chappell M, Rose J. Gender differences in effects of prenatal betamethasone exposure on sheep renal ACE and ACE2 activity: a possible mechanism in fetal programmed hypertension in males [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):275A.


Gwathmey TM, Zerihun L, Simington SW, Chappell MC, Washburn LK. Antenatal betamethasone exposure increases oxidative stress in African-American adolescents born prematurely [abstract]. Circulation. 2013;127():AP241.


Lindsey SH, da Silva AS, Silva MS, Chappell MC. Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation. Am J Physiol Endocrinol Metab. 2013;305(1):E113-E118.


Alzayadneh EM, Pirro NT, Chappell MC. Thimet oligopeptidase forms angiontensin-(1-7) in the nucleus of NRK-52E cells [abstract]. FASEB J. 2013;27():lb857.


Americao A, Pirro N, Brosnihan KB, Chappell M. Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. FASEB J. 2013;27():909.1.


Bi JL, Contag S, Su YX, Chen K, Figueroa J, Chappell M, Rose JC. Sex differences in oxidative stress following uniphrectomy in antenatal glucocorticoid exposed sheep [abstract]. FASEB J. 2013;27():733.2.


Guan MJ, Nautiyal M, Hakuda D, de Lima R, Rose J, Pirro NT, Chappell MC. Renal mitochondria predominantly express [des-Ang I]- angiotensinogen and renin [abstract]. FASEB J. 2013;27():909.5.


Schaich C, Nautiyal M, Howlett A, Chappell M, Diz D. Enhanced CB1 cannabinoid receptor tone contributes to impaired baroreflex sensitivity in hypertensive (mRen2)27 transgenic rats [abstract]. FASEB J. 2013;27():926.13.



Gwathmey TM, Alzayadneh EM, Pendergrass KD, Chappell MC. Novel roles of nuclear angiotensin receptors and signaling mechanisms. Am J Physiol Regul Integr Comp Physiol. 2012;302(5):R518-R530.


Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012;59(6):529-538.



Marshall AC, Shaltout HA, Nautiyal M, Chappell MC, Diz DI. Fetal betamethasone exposure and age influence the expression of AT7/mas receptors in the solitary tract nucleus [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.12.


Bi J, Su Y, Figueroa J, Chappell MC, Rose JC. Impact of antenatal betamethasone (B) on p47 phox in kidney and 8-isoprostane responses to angiotensin II in proximal tubule cells in male sheep after uninephrectomy [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.10.


Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012;302(11):F1374-84.


Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012;60(2):150-157.


Harrison-Bernard LM, Chappell MC. Unraveling the glomerular RAS: one peptidase at a time [editorial]. Am J Physiol Renal Physiol. 2012;303(3):F373-374.


Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI.Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension. 2012;60(5):1257-1265.


Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R799-806.


Gwathmey TM, Nixon P, Chappell M, Washburn L. 25-Hydroxyvitamin D and body mass index in female adolescents [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1093.15.


Santiago N, Melo MB, Chappell M, Varagic J, Santos RAS, Campagnole-Santos MJ.Diabetes abolishes the cardioprotective effect of estrogen on systolic cardiac function [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1057.23.


Chappell MC. Nonclassical renin-angiotensin system and renal function [abstract]. Compr Physiol. 2012;2(4):2733-2752.


Nautiyal M, Katakam PV, Busija DW, Chappell MC, Diz DI. Increased mitochondrial oxidative stress and activate AMP-kinase in the brain dorsal medulla of hypertensive (MRenw)27 transgenic rats [abstract]. Hypertension. 2012;60(Suppl 3):622.


Marshall AC, Shaltout HA, Nautiyal M, Chappell MC, Diz DI. Fetal betamethasone exposure enhances the peptide ration of angiotensin II to angiotensin-(1-7) in the dorsal medulla of adult sheep [abstract]. Hypertension. 2012;60(Suppl 3):118.


Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS ONE. 2011;6(1):e15759.


Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011;57(3):620-626.


Lindsey SH, Carver KA, Prossnitz ER, Chappell MC. Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol. 2011;57(5):598-603.



Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, Chappell MC, Wang H, Groban L. Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause. 2011;18(6):698-708.


Tang L, Bi J, Chappell M, Figueroa J, Rose JC. The effect of antenatal steroid exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.12.


Bi J, Tang L, Figueroa J, Chappell MC, Rose JC. Antenatal betamethasone (B) and gender affect 8-isoprostane responses to unilateral nephrectomy [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.11.


Lindsey SH, Bhat M, Aileru A, Chappell M. GPR30 attenuates functional AT1 receptor expression in rat mesenteric smooth muscle cells [abstract]. FASEB J. 2011;25(Meeting Abstracts):1088.8.


Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011;300(6):E979-985.


Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011;43(13):829-835.


Bi J, Figueroa JP, Chappell MC, Rose JC. Effect of prenatal betamethasone exposure on renal functional reserve in the young adult female sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):90A.


Su Y, Shaltout HA, Figueroa JP, Chappell M, Rose JC. Effect of early glucocorticoid treatment on GR and MR expression in adult sheep kidney [abstract]. Reprod Sci. 2011;18(4 Suppl):220A.


Zhang J, Massmann AG, Chappell MC, Figueroa JP. Antenatal glucocorticoids and diet-induced obesity alter adipose tissue function [abstract]. Reprod Sci. 2011;18(4 Suppl):223A.


Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.


Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.


Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Lively M, Ferrario CM.Localization and metabolism of angiotensin-(1-12) in human atrial tissue [abstract]. Hypertension. 2011;58(5):e50.


Alzayadneh EM, Bassosy H, Chappell M. Enhanced intracellular expression of nox4 and angiotensin II within the kidney of the diabetic female mRen2.Lewis rat [abstract]. Hypertension. 2011;58(5):e154.


El-Bassossy H, Lindsey SH, Yamaleyeva LM, Chappell MC. Renal GPR30 is upregulated in diabetes: association with renal protection in intact but not estrogen-depleted diabetic rats [abstract]. Hypertension. 2011;58(5):e152.


Gwathmey TM, Nixon PA, O'Shea TM, Brosnihan KB, Chappell MC, Washburn LK.Premature birth is associated with higher diastolic blood pressure and reduced vitamin D in African American adolescents [abstract]. Hypertension. 2011;58(5):e165.


Lindsey SH, da Silva A, Schaan BD, Chappell MC. GPR30-dependent relaxation of mesenteric arteries involves both nitric oxide and cyclic AMP activation of protein kinase G [abstract]. Hypertension. 2011;58(5):e180.


Lindsey SH, Yamaleyeva LM, Gallagher P, Chappell MC. GPR30 restores megalin expression in the renal cortex of salt-sensitive mRen2.Lewis females [abstract]. Hypertension. 2011;58(5):e182-e183.


Marshall A, Shaltout HA, Nautiyal M, Arter A, Chappell MC, Diz DI. Localization and regulation of angiotensin receptor subtypes in sheep solitary tract nucleus: effects of in utero exposure to glucocorticoid [abstract]. Hypertension. 2011;58(5):e75.


Muller C, Shewale S, Pirro N, Gurley SB, Brosnihan KB, Fiorino P, Chappell MC.Sex and species differences in ACE, ACE2 and neprilysin of the renal brush border [abstract]. Hypertension. 2011;58(5):e153.


Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Chronic intracerebroventricular angiotensin-(1-7) infusion, but not AT1 receptor blockade, improves vagal components of the baroreflex function in hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2011;58(5):e96.


Santiago NM, Yamaleyeva LM, Campagnole-Santos MJ, Chappell M, Varagic J.Early diabetes is associated with lower cardiac ACE2 activity but not altered blood pressure in female hypertensive mRen2.Lewis rats [abstract]. Hypertension. 2011;58(5):e126-e127.


Shaltout HA, Rose JC, Chappell MC, Diz DI. Ang-(1-7) deficiency and impairment of baroreflex for control of heart rate precede the antenatal betamethasone exposure-induced elevation in blood pressure [abstract]. Hypertension. 2011;58(5):e76.


Yamaleyeva LM, Gilliam-Davis SM, Chappell MC. Diabetes induces circulating ACE2 in hypertensive male and female rats but does not prevent increased plasma Ang II [abstract]. Hypertension. 2011;58(5):e38-e39.


Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS ONE. 2011;6(12):e28501.




Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.


Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC.Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010;55(1):166-171.


Diabetes, women's health issues