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Molecular and Cellular Biosciences at Wake Forest University

Wake Forest University Graduate School » Molecular and Cellular Biosciences

Michael C Seeds, Ph.D.

Michael C Seeds, Ph.D.
Education & Training
  BS University of Virginia 1976
  MS University of Virginia 1982
  PhD Wake Forest University 1987


Hite RD, Grier BL, Waite BM, Veldhuizen RA, Possmayer F, Yao L-J, Seeds MC.Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids. Am J Physiol Lung Cell Mol Physiol. 2012;302(2):L257-265.


Seeds MC, Grier BL, Suckling BN, Safta AM, Long DL, Waite BM, Morris PE, Hite RD. Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome. Am J Med Sci. 2012;343(6):446-451.


Updaw RJ, Hite R, Blair R, Ireland L, Grier B, Waite M, Seeds M. Cytokine regulation of secretory phospholipases A2 in a differentiated human monocyte cell model [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A5234.


Hite RD, Seeds MC, Morris PE, Grier BL, Waite BM, Douglas IS, Hudson LD, Goodman RB. Regulation of secretory A2 phospholipase activity in persistent ARDS [abstract]. Am J Respir Crit Care Med. 2010;181():A6474.


Hite RD, Seeds MC, Grier BL, Possmayer F, Veldhuizen RA, Waite BM. Regulation of hydrolysis by secretory phospholipases A2 in surfactant monolayer films [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A6278.


Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009;284(23):15400-7.


Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH. Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. Am J Respir Cell Mol Biol. 2009;41(3):358-366.


Lorenz E, Muhlebach MS, Tessier PA, Alexis NE, Hite RD, Seeds MC, Peden DB, Meredith W. Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases. Respir Med. 2008;102(4):567-573.


Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC. Mechanisms by which botanical lipids affect inflammatory disorders. Am J Clin Nutr. 2008;87(2 Suppl):498S-503S.


Hite RD, Hastie AT, Seeds MC, Grier BL, Peters SP, Moore WC, Bleecker ER.Surfactant alterations in asthmatics from the Wake Forest Severe Asthma Research Program Center [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A100.


Blair RA, Hite RD, Seeds MC. Regulation of GP IIA sPLA2 mRNA production in a human monocyte cell model (THP-1) [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A750.


Pascual RM, Seeds MC, Panettieri RA, Peters SP, Penn RB. Interleukin-1beta (IL-1beta)-mediated microsomal prostaglandin E2(PGE2) synthase (mPGES) induction regulates cyclooxygenase-2 (COX-2) and PGE2 production in human airway smooth muscle (HASM) [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A663.



El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR.Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111(1):36-44.


Inflammation and host defense in the lung; regulation of secretory phospholipases A2; differential regulation of granulocyte apoptosis.