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Molecular and Cellular Biosciences at Wake Forest University


Wake Forest University Graduate School » Molecular and Cellular Biosciences

Nicholette Allred, Ph.D.

Nicholette Allred, Ph.D.
Education & Training
BS University of North Carolina at Charlotte 2001
PhD Wake Forest School of Medicine 2005
Memberships
American Society of Human Genetics
American Diabetes Association

 

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI.Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

 

An SS, Palmer ND, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin. Genet Epidemiol. 2013;37(1):13-24.

 

Ng MCY, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD,.Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Diabetes. 2013;62(3):965-976.

 

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,.Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

 

Palmer ND, Freedman BI. Diabetic nephropathy: FRMD3 in diabetic nephropathy-guilt by association. Nat Rev Nephrol. 2013;9(6):313-314.

 

Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45(6):690-696.

 

Palmer ND, Freedman BI. Diabetic nephropathy: FRMD3 in diabetic nephropathy--guilt by association [comment]. Nat Rev Nephrol. 2013;9(6):313-314.

 

Ng MCY, Hester JM, Wing MR, Li J, Xu J, Hicks PJ, Roh BH, Lu L, Divers J, Langefeld CD, Freedman BI, Palmer ND, Bowden DW. Genome-wide association of BMI in African Americans. Obesity (Silver Spring). 2012;20(3):622-627.

 

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Lu L, Ziegler JT, Divers J, Ng MCY, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE. 2012;7(1):e29202.

 

Cooke JN, Ng MCY, Palmer ND, An SS, Hester JM, Freedman BI, Langefeld CD, Bowden DW. Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care. 2012;35(2):287-292.

 

Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MCY. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465-473.

 

Palmer ND, Freedman BI. Insights into the genetic architecture of diabetic nephropathy. Curr Diab Rep. 2012;12(4):423-431.

 

An SS, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen Y-DI, Wagenknecht LE, Langefeld CD, Bowden DW, Palmer ND.Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study. Mol Genet Metab. 2012;107(4):721-728.

 

Speliotes EK, Harnaez R, Feitosa MF, Palmer ND, Peyser PA, Harris TB, Wagenknecht LE, Liu J, Kahali B, Carr JJ, Smith AV, Musani SK, Borecki IB, Bielak LF, Yerges-Armstrong LM. Genetic variants predispose to nonalcoholic fatty live disease across ancestries [abstract]. Hepatology. 2012;56(Suppl 1):242A.

 

McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MCY, Divers J, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2011;79(5):563-572.

 

Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MCY, Bowden DW. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes. 2011;60(2):662-668.

 

Wagenknecht LE, Palmer ND, Bowden DW, Rotter JI, Norris JM, Ziegler J, Chen YI, Haffner S, Scherzinger A, Langefeld CD. Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study. Liver Int. 2011;31(3):412-416.

 

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW, et al. Differential effects of MYH9 and APOL1 risk variants on FRMD3 association with diabetic ESRD in African Americans. PLoS Genet. 2011;7(6):e1002150.

 

Wing MR, Ziegler JM, Langefeld CD, Roh BH, Palmer ND, Mayer-Davis EJ, Rewers MJ, Haffner SM, Wagenknecht LE, Bowden DW. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes (Lond). 2011;35(9):1173-1182.

 

Hellwege JN, Hicks PJ, Palmer ND, Freedman BI, Bowden DW. Examination of rare variants in HNF4 alpha in European Americans with type 2 diabetes [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

 

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic risk assessment of type 2 diabetes associated polymorphisms in African-Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

 

Ehret GB, Munroe PB, Rice KM, Liu Y, Palmer ND, Lohman KK, Rudock ME, Langefeld CD, Prokopenko I, Wagenknecht LE, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478(7367):103-109.

 

Palmer ND, Langefeld CD, Ziegler JT, Hsu F, Haffner SM, Fingerlin T, Norris JM, Chen YI, Rich SS, Bowden DW, et al. Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study. Diabetologia. 2010;53(2):281-289.

 

Palmer ND, Mychaleckyj JC, Langefeld CD, Ziegler JT, Williams AH, Bryer-Ash M, Bowden DW. Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study. Diabetes Res Clin Pract. 2010;87(1):69-76.

 

Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MCY, Lu L, Langefeld CD, Freedman BI, Bowden DW. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics. 2010;96(4):211-219.

 

Bowden DW, An SS, Palmer ND, Brown WM, Norris JM, Haffner SM, Hawkins GA, Guo X, Wagenknecth LE, Langefeld CD, et al. Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet. 2010;19(20):4112-4120.

 

Bowden DW, Akamizu T, Palmer ND, An S, Brown MD, Haffner SM, Norris JM, Rotter JI, Guo XQ, Chen I. Identification and evaluation of an ADIPOQ gene mutation in Hispanic American families from the Insulin Resistance Atherosclerosis Family Study [abstract]. Endocr J. 2010;57(Suppl 2):S329.

 

Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, Fingerlin TE, Wagenknecht LE, Bowden DW, Langefeld CD, et al. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS Family Study. J Steroid Biochem Mol Biol. 2010;122(4):186-192.

 

Mcdonough CW, Allred ND, Hicks PJ, Bostrom MA, Lu L, Ng M, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome wide association study for diabetic nephropathy genes in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

 

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Allred ND, Hicks PJ, Bostrom MA, Cooke JN, Mcdonough CW, Bowden DW, et al. Accounting for risk variants in MYH9 reveals FRMD3 association with diabetic ESRD in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):728A.

 

Goodarzi MO, Palmer ND, Stefanovski D, Taylor KD, Jones MR, Cui J, Guo X, Chen YDI, Wagenknecht LE, Bowden DW, et al. Exostosin 2: a replicated quantitative trait locus for insulin clearance [abstract]. Endocr Rev. 2010;31(3 Suppl 1):S549.

 

Sutton BS, Palmer ND, Langefeld CD, Xue B, Proctor A, Ziegler JT, Haffner SM, Norris JM, Bowden DW. Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2009;58(6):1457-1462.

 

Rich SS, Goddarzi MO, Palmer ND, Langefeld CD, Ziegler J, Haffner SM, Bryer-Ash M, Norris JM, Wagenknecht LE, Bowden DW, et al. A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia. 2009;52(7):1326-1333.

 

Bowden DW, Allred NP, Ng MC, Langefeld CD, Freedman BI. Genome wide analysis of African American type 2 diabetes [abstract]. Diabetologia. 2009;52(Suppl 1):S37.

 

Hester JM, Palmer ND, Ng MCY, Adeyemo A, Rotimi C, Freedman BI, Bowden DW.Comprehensive genetic evaluation of variation at the TCF7L2 locus in African Americans [abstract]. Diabetes. 2009;58(Suppl 1):A304.

 

McDonough CW, Palmer ND, Bostrom MA, Hicks PJ, Lu L, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome-wide association study (GWAS) of diabetic nephropathy (DN) in African Americans (AA) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):433A.

 

Palmer ND, Lehtinen AB, Langefeld CD, Campbell JK, Haffner SM, Norris JM, Bergman RN, Goodarzi MO, Rotter JI, Bowden DW. Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab. 2008;93(1):304-309.

 

Palmer ND, Goodarzi MO, Langefeld CD, Ziegler J, Norris JM, Haffner SM, Bryer-Ash M, Bergman RN, Wagenknecht LE, Bowden DW, et al. Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2008;57(4):1093-1100.

 

Hicks PJ, Staten JL, Palmer ND, Langefeld CD, Ziegler JT, Keene KL, Sale MM, Bowden DW, Freedman BI. Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease. Am J Nephrol. 2008;28(6):914-920.

 

Lewis JP, Palmer ND, Hicks PJ, Sale MM, Langefeld CD, Freedman BI, Divers J, Bowden DW. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes. 2008;57(8):2220-2225.

 

Bowden DW, Lewis JP, Allred ND, Langefeld CD, Divers J, Freedman BI. Genetic analysis of 'European' type 2 diabetes SNPs from whole genome association studies in African Americans [abstract]. Diabetologia. 2008;51(Suppl 1):S129.

 

Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Bowden DW, et al. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics. 2008;92(4):226-234.

 

Palmer ND, Langefeld CD, Bryer-Ash M, Rotter JI, Taylor KD, Bowden DW.Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. J Clin Endocrinol Metab. 2008;93(12):4979-4983.

 

Characterization of human genetic variation and application of this information to understand common human diseases such as type 2 diabetes. This research combines approaches from population genetics, molecular biology, and epidemiology.