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Molecular and Cellular Biosciences at Wake Forest University


Wake Forest University Graduate School » Molecular and Cellular Biosciences

Thomas C. Register, Ph.D.

Thomas C. Register, Ph.D.
Professor, Pathology-Comparative Medicine Center for Biomolecular Imaging
Arthritis-Musculoskeletal DRC
Sticht Center on Aging
Center for Diabetes Research
WFU Primate Center
Orthopaedics
Radiology
 
Clinical Specialties

Hormone Replacement Therapy and Menopause , Atherosclerosis , Imaging , Endocrine/Menopausal Management , Osteoporosis

Education & Training
  BS Francis Marion University 1978
  BS Francis Marion University 1979
  PhD University of South Carolina-Columbia 1985
Fellowship   WFU School of Medicine 1988
Memberships
N American Vascular Biology Organization
American Association of Clinical Chemistry
American Heart Association
American Society of Bone & Mineral Research
Endocrine Society

 

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI.Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC.Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013;20(5):540-547.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874-886.

Barascuk N, Genovese F, Larsen L, Byrjalsen I, Zheng Q, Sun S, Hosbond S, Poulsen TS, Diederichsen A, Jensen JM, Mickley H, Register TC, Rasmussen LM, Leeming DJ, Christiansen C, Karsdal MA. A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease. Int J Clin Exp Med. 2013;6(3):174-184.

Willard S, Johnston WD, Clark A, Uberseder B, Neely D, Massey A, Daunais J, Williamson J, Register TC, Bourland JD, Shively C. Long term sertraline treatment decreases volumes of hippocampus and anterior cingulate cortex in an adult female primate model of depression [abstract]. Biol Psychiatry. 2013;73(9 Suppl):235S.

Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013;20(7):777-784.

Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM. Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Cancer Prev Res (Phila Pa). 2013;6(8):832-842.

Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL. Development of amyloid burden in African Green monkeys. Neurobiol Aging. 2013;34(10):2361-2369.

Wood CE, Boue SM, Collins-Burow BM, Rhodes LV, Register TC, Cline JM, Dewi FN, Burow ME. Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. J Agric Food Chem. 2012;60(1):81-86.

Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012;133(2):617-634.

Freedman BI, Register TC. Effect of race and genetics on vitamin D metabolism, bone and vascular health. Nat Rev Nephrol. 2012;8(8):459-466.

Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O.Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012;47(8):601-607.

Shively CA, Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritchevsky SB. Aging and physical mobility in group-housed Old World monkeys. Age (Dordr). 2012;34(5):1123-1131.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012;13(1):148.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE.The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012;19(10):1074-1080.

Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012;19(11):1242-1252.

Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17 beta-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res. 2011;1379():11-22.

Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011;1379():23-33.

Shively CA, Willard SL, Higley JD, Register TC. The effects of sertraline HCl on depressed adult female nonhuman primates [abstract]. Biol Psychiatry. 2011;69(9 Suppl):128S.

Willard SL, Register TC, Kritchevsky SB, Shively CA. Effects of menstrual cycle and social stress on circulating brain-derived neurotrophic factor in female monkeys [abstract]. Biol Psychiatry. 2011;69(9 Suppl):219S-220S.

Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-1560.

Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA.Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Physiol Behav. 2011;104(2):222-227.

Barascuk N, Vassiliadis E, Larsen L, Wang J, Zheng Q, Xing R, Cao Y, Crespo C, Lapret I, Register TC, et al. Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen--a novel biomarker of atherosclerotic plaque remodeling. Clin Biochem. 2011;44(10-11):900-906.

Turner RJ, Bushnell CD, Register TC, Sharp FR. Gender-dependent correlations of carotid intima-media thickness with gene expression in blood. Transl Stroke Res. 2011;2(2):171-178.

Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritschevsky SB [sic] [Kritchevsky SB], Shively CA.Developing models of aging and physical function in three species of old world monkeys [abstract]. Am J Primatol. 2011;73(Suppl 1):81.

Eyster KM, Appt SE, Mark-Kappeler CJ, Chalpe A, Register TC, Clarkson TB. Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery. Menopause. 2011;18(10):1087-1095.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower RC, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):715A.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB.An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Menopause. 2011;18(12):1352.

Barascuk N, Ganz M, Nielsen M, Register TC, Rasmussen LM, Karsdal MA, Christiansen C. Abdominal aortic calcification quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) index is associated with features of the metabolic syndrome. BMC Cardiovasc Disord. 2011;11():75.

Burdon KP, Rudock ME, Lehtinen AB, Langefeld CD, Bowden DW, Register TC, Liu Y, Freedman BI, Carr JJ, Hedrick CC, et al. Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the Diabetes Heart Study. Mediators Inflamm. 2010;2010():170153.

Groban L, Jessup J, Register T. Early estrogen replacement prevents lusitropic impairment following ovariectomy in middle-aged cynomolgus monkeys [abstract]. J Am Coll Cardiol. 2010;55(10A):A38.

Barascuk N, Skjot-Arkil H, Register TC, Larsen L, Byrjalsen I, Christiansen C, Karsdal MA. Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes. BMC Cardiovasc Disord. 2010;10():article 19.

Sophonsritsuk A, Appt SE, Clarkson TB, Register TC. Estrogen therapy and cardiovascular disease: could arterial expression of interleukin 17 provide some answers to the timing hypothesis? A study of early and late menopause in non-human primates [abstract]. Fertil Steril. 2010;94(4 Suppl 1):S43-S44.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Register TC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study. J Clin Endocrinol Metab. 2010;95(12):5382-5389.


Register T, Sophonsritsuk A, Appt SE. Estrogen inhibits carotid artery inflammation in early but not late menopause in cynomolguis [sic]monkeys [abstract]. Menopause. 2010;17(6):1216.

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

Wood CE, Register TC, Cline JM. Transcriptional profiles of progestogen effects in the postmenopausal breast. Breast Cancer Res Treat. 2009;114(2):233-242.

Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009;71(9):742-751.


Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis in female primates.. Obesity (Silver Spring). 2009;17(8):1513-1520.

Kavanagh K, Davis MA, Zhang L, Wilson MD, Register TC, Adams MR, Rudel LL, Wagner JD. Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA: cholesterol acyltransferase 2 (ACAT2) in monkeys. Arterioscler Thromb Vasc Biol. 2009;29(10):1471-1477.

Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24(10):1719-1727.

Shively CA, Register TC, Kritchevsky S, Carr JJ, Kaplan JR, Jorgensen MJ, Bennett AJ. A primate model of physical function [abstract]. Gerontologist. 2009;49(Suppl 2):65-66.

Carr JJ, Register TC, Hsu F-C, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Wagenknecht LE, Freedman BI, et al. Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the Diabetes Heart Study. Bone. 2008;42(1):43-52.

Walker SE, Adams MR, Franke AA, Register TC. Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys. Atherosclerosis. 2008;196(1):106-113.

Shively CA, Register TC, Willard SL. Behavioral adaptation to social rank change in adult female macaca fascicularis [abstract]. Am J Primatol. 2008;70(Suppl 1):62.

Arifin E, Shively CA, Register TC, Cline JM. Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis). Vet Pathol. 2008;45(4):512-515.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB.Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys. Psychosom Med. 2008;70(6):637-645.

Bielinski SJ, Pankow JS, Foster CL, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, et al. Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination. Atherosclerosis. 2008;199(1):172-178.

Scott LM, Xu X, Veenstra TD, Tooze JA, Wood CE, Register TC, Kock ND, Cline JM.Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis). Cancer Epidemiol Biomarkers Prev. 2008;17(10):2594-2602.

Walker SE, Register TC, Appt SE, Adams MR, Clarkson TB, Chen H, Isom S, Franke AA, Kaplan JR. Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. Menopause. 2008;15(5):950-957.

Cann JA, Register TC, Adams MR, St. Clair RW, Espeland MA, Williams JK. Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice. Atherosclerosis. 2008;201(1):43-52.

McKimmie RL, Daniel KR, Carr JJ, Bowden DW, Freedman BI, Register TC, Hsu F-C, Lohman KK, Weinberg RB, Wagenknecht LE. Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol. 2008;103(12):3029-3035.

Scott LM, Durant P, Leone-Kabler S, Wood CE, Register TC, Townsend A, Cline JM.Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes. J Steroid Biochem Mol Biol. 2008;112(4-5):179-185.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB.Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys [abstract]. Menopause. 2008;15(6):1211.

Lehtinen AB, Burdon KP, Lewis JP, Langefeld CD, Ziegler JT, Rich SS, Register TC, Carr JJ, Freedman BI, Bowden DW. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. J Clin Endocrinol Metab. 2007;92(1):345-352.


Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Cline JM. Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys. Breast Cancer Res Treat. 2007;101(2):125-134.

Sastry KSR, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G, et al. Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem. 2007;282(19):14094-100.

Register TC, Walker SE, Shively CA, Adams MR, Kaplan JR, Appt SE, Clarkson TB.Inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis) [abstract]. Am J Primatol. 2007;69(Suppl 1):72.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB.Depression and coronary artery atherosclerosis in adult female Macaca fascicularis [abstract]. Am J Primatol. 2007;69(Suppl 1):73.

Wood CE, Register TC, Cline JM. Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys. Carcinogenesis. 2007;28(4):801-808.

Lees CJ, Kaplan JR, Chen H, Jerome CP, Register TC, Franke AA. Bone mass and soy isoflavones in socially housed, premenopausal macaques. Am J Clin Nutr. 2007;86(1):245-250.

Wood CE, Sitruk-Ware RL, Tsong Y-Y, Register TC, Lees CJ, Cline JM. Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model. Menopause. 2007;14(4):639-647.

Shively CA, Wood CE, Register TC, Willard SL, Lees CJ, Chen H, Sitruk-Ware RL, Tsong Y-Y, Cline JM. Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys. Psychoneuroendocrinology. 2007;32(8-10):981-990.

Bielinski SJ, Pankow JS, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK. Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination. Genes Immun. 2007;8(8):684-690.

Stute P, Wood CE, Register TC, Lees CJ, Kiesel L, Sieberns K, Cline MJ [sic] [Cline JM]. Life stage differences in mammary gland gene expression profile [abstract]. Menopause. 2007;14(6):1081.

 

Aging, cross(mult/tnslat/inter)discip, genetics/genome, obesity, osteoporosis, radiology/imaging.